Abstract

Background: Burns are traumatic injuries caused by thermal, chemical, or other external factor, significantly impacting organic tissue. They are among the most common and severe types of trauma worldwide, often resulting in considerable morbidity and mortality. Natural products, owing to their pharmacological properties, present promising avenues for burn management and treatment.

Purpose: This study aims to provide a comprehensive review of patented pharmaceutical formulations containing natural products for burn treatment and to define trends in the market.

Methods: Patent documents were identified through searches in the World Intellectual Property Organization (WIPO) and European Patent Office (EPO) databases using "burn*" as a keyword in the title and/or abstract and International Patent Classification (IPC) code A61K36/00. The review also examines clinical trials and SWOT analyses to evaluate strengths, weaknesses, opportunities, and threats in this field.

Results: A total of 82 patents were selected, highlighting the use of natural products, such as Aloe vera, Coptis chinensis, borneol, menthol, and propolis, predominantly derived from Traditional Chinese Medicine. These findings are supplemented with clinical trial data and market insights. The results underscore both the therapeutic efficacy and challenges, such as standardization and regulatory hurdles, of using natural products.

Conclusion: This patent review highlights the potential of natural-origin formulations in addressing the limitations of conventional burn treatments. Continued research is essential to overcome existing barriers, ensuring broader accessibility and enhanced therapeutic outcomes.

למאמר המלא

Nascimento Júnior JAC, Oliveira AMS, Porras KDL, Menezes PDP, Araujo AAS, Nunes PS, Aragón DM, Serafini MR. Exploring trends in natural product-based treatments to skin burn: A comprehensive review. Phytomedicine. 2025 Apr;139:156481. doi: 10.1016/j.phymed.2025.156481. Epub 2025 Feb 7. PMID: 39951972.